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Menstrual-like vaginal bleeding in prepubertal girls: an unexplained condition
The mutation occurs in a postzygotic cell line and exists in a mosaic configuration. These children will go on to normal puberty. In stark contrast, girls with vaginal bleeding in the setting of primary hypothyroidism have linear growth failure and symptoms such as decreased energy, cold intolerance, and constipation. Haddad, N, Eugster, E. J Clin Endocrinol Metab. A suppressed response of gonadotrophins is seen in other causes of peripheral precocious puberty such as adrenal and ovary tumors.